Professional, Scientific, and Technical Services ·NAICS 541714

NAICS 541714 · IRS SOI (C corp) · Census CBP 2023

Research and Development in Biotechnology (except Nanobiotechnology) - Industry Benchmarks

$184,984/yr average annual pay, with 98 SBA loans on record for NAICS 541714.

3.9%
Professional, Scientific, and Technical Services sector margin
195K
Workers employed
$184,984/yr
Avg payroll / employee
$78M
SBA lending, FY20–26

Data updated August 2026

The verdict · NAICS 541714

California leads Research and Development in Biotechnology (except Nanobiotechnology) activity nationally. IRS SOI doesn't publish margin data at this NAICS level, but the broader Professional, Scientific, and Technical Services sector runs a 3.9% net margin.

3.9%
Professional, Scientific, and Technical Services sector margin (IRS SOI)
195K
Workers employed (Census CBP)
$184,984/yr
Avg payroll / employee
$78M
SBA lending, FY20–26

Use Research and Development in Biotechnology (except Nanobiotechnology)'s NAICS benchmark as a comparison point, not a forecast for one business.

Research and Development in Biotechnology (except Nanobiotechnology) is reported here with financial measures from IRS Statistics of Income and workforce measures from Census County Business Patterns. The page keeps those source systems distinct, shows unavailable fields rather than estimating them, and links the underlying industry context so readers can compare the same NAICS activity before interpreting a margin or payroll figure.

Source: IRS SOI (C corporation headline) and Census County Business Patterns 2023

Benchmarking Insights for Research and Development in Biotechnology (except Nanobiotechnology)

Research and Development in Biotechnology (except Nanobiotechnology) sits inside Professional, Scientific, and Technical Services, a sector that runs a 3.9% net margin overall.

5,670 establishments employ 194,991 workers (34.4/location) at $184,984/yr average annual pay. California leads employment, followed by Massachusetts and New Jersey.

Research and Development in Biotechnology (except Nanobiotechnology) sits in the 85th percentile for employment among 6-digit NAICS industries with reported data.

Employment

194,991

Total employees (Census CBP)

Avg Payroll / Employee

$184,984/yr

Annual compensation

Establishments

5,670

Business locations

Release-over-release change

What changed from Census CBP 2022 to 2023

Employment increased by 41,220; establishment count increased by 341. This comparison uses two published national Census County Business Patterns releases; suppressed fields are omitted rather than estimated.

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Workforce scale

Financial Detail

Annual Payroll (Total)
$36.1B
Avg Employees per Establishment
34.4

Top States by Employment

State Employment
California 65,114
Massachusetts 35,946
New Jersey 10,031
Pennsylvania 7,937
Maryland 7,304
Washington 6,223
Texas 4,041
Virginia 2,741
Wisconsin 1,911
Illinois 1,833

Showing top 10 of 51 states

SBA Lending Activity

SBA FY2020–2026

SBA Loans Approved

98

Total Loan Volume

$78M

Avg Loan Size

$794K

Jobs Supported

844

Program Breakdown

7(a) 78 (80%)
504 20 (20%)

Top SBA Lender

Newtek Bank, National Association

8 loans in this industry

New Business Share

24.5% of borrowers were new/startup businesses

Annual Lending Trend (7 yrs)

2020
12
2021
13
2022
12
2023
12
2024
24
2025
23
2026
2

View SBA lending rankings →

Frequently Asked Questions

How profitable is Research and Development in Biotechnology (except Nanobiotechnology)?
IRS SOI doesn't publish margin data at the NAICS 541714 level. California leads this industry nationally. The broader Professional, Scientific, and Technical Services sector runs a 3.9% net margin (IRS SOI 2013 C corp).
How many businesses are in Research and Development in Biotechnology (except Nanobiotechnology)?
5,670 business establishments. Together they employ 194,991 workers.
What is the average payroll per employee in Research and Development in Biotechnology (except Nanobiotechnology)?
$184,984/yr average annual pay per employee. Businesses average 34.4 employees per establishment.
Which states have the most Research and Development in Biotechnology (except Nanobiotechnology) employment?
California leads with 65,114 workers. Massachusetts (35,946) and New Jersey (10,031) round out the top three.
How much SBA lending does Research and Development in Biotechnology (except Nanobiotechnology) receive?
Research and Development in Biotechnology (except Nanobiotechnology) businesses received 98 SBA loans totaling $78 million between FY2020 and FY2026. The average loan size was $794K. These loans supported 844 jobs at origination. Most lending (80%) came through the SBA 7(a) program.

Nationwide industries with similar benchmark drivers

Two IRS/Census peer sets for Research and Development in Biotechnology (except Nanobiotechnology), both at NAICS level 6 and excluding this code so the neighborhoods are not self-links.

According to Census County Business Patterns 2023, Research and Development in Biotechnology (except Nanobiotechnology) ranks #121 of 801 U.S. industries at the 6-digit NAICS level by total employment.

Read with this industry: Industry employment trends · Professional, Scientific, and Technical Services · Rankings

Disclaimer: Public IRS/Census data, not financial or tax advice. See our full disclaimer.

Sources: IRS Statistics of Income (SOI) Business Tax Statistics · Census Bureau County Business Patterns 2023

NAICS 541714 · CBP 2023 · IRS SOI

According to the U.S. Census Bureau, which released its 2023 County Business Patterns dataset in June 2025, PlainBizBench benchmarks 2,002 U.S. industries against Internal Revenue Service Statistics of Income data. See our methodology for the full compilation process.

Read our methodology - how this data is sourced, computed, and verified.

Source: U.S. Census Bureau, County Business Patterns / SUSB Industry employment scale, payroll, and firm-size benchmarks · 2023

Every figure on PlainBizBench is rendered directly from federal source data, no number is typed in by an editor. This page aggregates profit-margin, payroll, entity-type, and SBA-lending benchmarks for this industry, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.

Disclaimer: Public IRS/Census data, not financial or tax advice. See our full disclaimer.